Macrolides and analogues
Apexbio Technology LLC EPOTHILONE B 100MG
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Abcam Epothilone D, Microtubule-stabilizing agent, 1MG
MW 491.7 Da. Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Zearalenone
Chemical. CAS 17924-92-4. Formula C18H22O5. MW 318.4. Isolated from Fusarium graminearum. Resorcylic acid lactone. Mycotoxin. Regulator of fungal morphogenesis. Mycoestrogen with anabolic and uterotrophic activity. Ecdysteroid antagonist. Gonadotropin inhibitor. Interleukin antagonist. Apoptosis inducer. Analytical standard in food industry.
Abcam Epothilone B, Microtubule stabilizing agent, 100UG
MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical 5Z 11Z 15R15HydroxyeIcosa
A potent inhibitor of B-RafV600E (Kd 14 nM in an in vitro binding assay) blocks B-RafV600E dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s 78 and 60 nM respectively) displays good oral bioavailability
Cayman Chemical 5Z 11Z 15R15HydroxyeIcosa
A potent inhibitor of B-RafV600E (Kd 14 nM in an in vitro binding assay) blocks B-RafV600E dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s 78 and 60 nM respectively) displays good oral bioavailability
Apexbio Technology LLC EPOTHILONE B 1ML
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Apexbio Technology LLC ZEARALENONE 10MG
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Apexbio Technology LLC 5Z-7-OXOZEAENOL 1MG
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Selleck Chemical LLC Zearalenone
Zearalenone (F2 toxin RAL) is a non-steroidal estrogenic mycotoxin that acts by binding the estrogen receptor (ER)
TARGETMOL CHEMICALS INC ZEARALENONE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Zearalenone (F2 toxin) is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in cattle pigs and sheep with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts. purity: 99%
Apexbio Technology LLC ZEARALENONE 5MG
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Apexbio Technology LLC 5Z-7-OXOZEAENOL 5MG
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models