Macrolides and analogues
Apexbio Technology LLC Epothilone D 189453-10-9 10mg
Epothilone D (189453-10-9) is a small-molecule microtubule-stabilizing agent It is designed to stabilize microtubules thereby disrupting essential cellular processes such as mitosis Epothilone D exerts its biological activity primarily through inhibition of microtubule depolymerization In in vitro assays Epothilone D demonstrates cytotoxic activity with IC50 values of 2 9 nM in MCF-7 cells 2 7 nM in KB-31 cells and 9 5 nM in CCRF-CEM cells Based on these pharmacological properties Epothilone D holds research potential in oncology and the study of drug resistance in cancer
Medchemexpress LLC Epothilone F | 208518-52-9 | 99.5% | 100 MG
Epothilone F is a 16-membered macrolide microtubule-targeting agent. It demonstrates significant anticancer activity, particularly against paclitaxel-resistant cancer cells. It inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells, and is widely used in cancer-related research.
- Microtubule-targeting agent
- Exhibits significant anticancer activity
- Effective against paclitaxel-resistant cancer cells
- Inhibits proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells
- Used in cancer-related research
- Cytotoxicity against mouse L929 cells with an IC50 of 1.5 ng/mL
Medchemexpress LLC 5Z-7-Oxozeaenol | 253863-19-3 | 99.3% | 1 ML
5Z-7-Oxozeaenol is a natural anti-protozoan compound originating from fungi. It functions as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2, which helps prevent inflammation. This compound is intended for research applications only.
- Potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2
- Inhibits the JNK/p38 pathway in a signal-specific manner
- Suppresses PMA-induced AP-1 activity in KT cells
- Shows inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC
Cayman Chemical 5Z 11Z 15R15HydroxyeIcosa
A stable isomer of 15(S)-HETE that elicits contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of PC-3 cells
Medchemexpress LLC 5Z-7-oxozeaenol | 253863-19-3 | MFCD12912700 | 99.6% | 362.37 g/mol | C19H22O7 | 5 MG
5Z-7-Oxozeaenol is a natural, fungal-derived small molecule that acts as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2. It is used in biochemical and cellular research to probe TAK1- and VEGFR2-mediated signaling; reported IC50 values are 8 nM for TAK1 and 52 nM for VEGF-R2. The compound is supplied as a solid with high purity suitable for research applications.
- Potent, irreversible inhibition of TAK1 (IC50 = 8 nM).
- Selective activity against VEGF-R2 (IC50 = 52 nM).
- High purity suitable for biochemical and cellular assays.
- Solid form convenient for handling and storage.
- Useful for studying MAPKKK-mediated signaling pathways.
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 10mM (in 1mL DMSO), CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Cayman Chemical 5Z 2E-CU-3 10mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 5mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Medchemexpress LLC Zearalenone-13C18 | 911392-43-3 | 98.7% | 336.23 g/mol | 13C18H22O5 | 30 UG
Zearalenone-13C18 is a fully 13C-labeled isotopic internal standard of the mycotoxin zearalenone, intended for use as an analytical reference in GC- and LC-MS quantification. The compound has CAS number 911392-43-3, molecular formula 13C18H22O5, and molecular weight 336.23 g/mol. It is supplied as a pre-weighed quantity for analytical laboratory use.
- Fully 13C-labeled internal standard for mass spectrometry.
- High purity (98.7%) to support accurate quantification.
- Suitable for GC- and LC-MS analytical methods.
- Supplied as a 30 μg pack for trace-level analyses.
Medchemexpress LLC Epothilone F | 208518-52-9 | 99.0% | 10 MG
Epothilone F is a 16-membered macrolide microtubule-targeting agent. It exhibits significant anticancer activity and is particularly effective against paclitaxel-resistant cancer cells. This compound inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells, making it widely used in cancer-related research.
- Functions as a microtubule-targeting agent.
- Demonstrates significant anticancer activity.
- Effective against paclitaxel-resistant cancer cells.
- Inhibits proliferation of breast, non-small cell lung, and drug-resistant ovarian cancer cells.
- Widely used in cancer-related research.
- Exhibits cytotoxicity against mouse L929 cells with an IC50 of 1.5 ng/mL.
Medchemexpress LLC Epothilone F | 208518-52-9 | 99.45% | 1 MG
Epothilone F is a 16-membered macrolide microtubule-targeting agent that demonstrates significant anticancer activity. It effectively inhibits paclitaxel-resistant cancer cells and has been widely applied in cancer-related research, specifically showing inhibitory effects on the proliferation of breast, non-small cell lung, and drug-resistant ovarian cancer cells.
- Potent microtubule-targeting agent.
- Exhibits significant anticancer activity.
- Effective against paclitaxel-resistant cancer cells.
- Inhibits proliferation of breast, non-small cell lung, and drug-resistant ovarian cancer cells.
- Widely used in cancer research.
- Store at -20°c, protect from light.
- Stock solutions in solvent: -80°c for 6 months; -20°c for 1 month (protect from light).
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 5mg, CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies
Apexbio Technology LLC Epothilone B (EPO906, Patupilone)(Synonyms: Patupilone, EPO906, Epothilone B, (-)-Epothilone B, Epothilone B lactam), 100mg, CAS: 152044-54-7.
Epothilone B (EPO906 Patupilone CAS 152044-54-7) is a naturally occurring macrocyclic lactone initially isolated from the myxobacterium Sorangium cellulosum Sharing a mechanism of action similar to paclitaxel Epothilone B stabilizes microtubules thereby inhibiting cellular mitosis In vitro Epothilone B displays potent cytotoxic activity with an EC0 01 of approximately 1 8 nM Importantly Epothilone B effectively counters resistance mediated via P-glycoprotein which confers paclitaxel resistance and exhibits superior aqueous solubility compared to paclitaxel Research indicates Epothilone B treatment elevates intracellular free calcium and cytosolic cytochrome C in ovarian cancer SKOV-3 cells highlighting its utility as a research tool in cancer biology and chemotherapy resistance studies